BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at Email is hidden with your resume or apply through the links below.

- Senior Software Engineer, Frontend: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Senior Bioinformatics Engineer, Prenatal: https://job-boards.greenhouse.io/billiontoone/jobs/449603100...

- Director, AI Engineering: https://job-boards.greenhouse.io/billiontoone/jobs/449575500...

- Director of IT: https://job-boards.greenhouse.io/billiontoone/jobs/455290000...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.

Strider Technologies | SLC,UT or Tyson's Corner VA USA| AI Engineers, Data Collection Engineers (Scrapy/Playwright) | $120k–$160k

Strider Technologies does strategic intelligence to enable faster, more confident decision-making for organizations around the world. To do this, we need data collection engineers(web scrapers) we use scrapy and playwright to do this. also AI engineers to make sense of all the documents we collect.

Software Engineer Data Collection: https://grnh.se/bba928f06us AI Engineer: https://grnh.se/7lnvkl006us All Roles: https://grnh.se/a2d832166us

Wearlinq | San Francisco, REMOTE (US) | Lead AI Engineer

Wearlinq is making cardiovascular disease prevention personal and intelligent through hardware, AI, and services - we're looking for a top engineer to lead our AI efforts after closing out our latest round (not yet announced).

Reach out at Email is hidden or apply at https://wearlinq.breezy.hr/p/1b9f2f7fa60d

Unto Labs | San Francisco, CA | ONSITE (Hybrid OK), REMOTE (US) | Full-Time

Unto Labs is developing the Thru Layer-1 blockchain (https://thru.org)

We recently announced $14.4 million in funding to make blockchains & digital assets useful for the world. Founded by Jump Crypto alumni and core contributors to the Solana protocol and the Firedancer client (https://github.com/firedancer-io/firedancer), we’re tackling fundamental scalability, performance, and usability challenges in distributed ledgers.

Our runtime conforms to the RISC-V specification—moving away from domain-specific VMs, DSLs, and bespoke compiler toolchains that limit developer and institutional adoption. You can write smart contracts and programs in any LLVM compatible programming language and reason about a standard ISA in RISC-V. Components are developed in C for maximal control over performance and resource usage.

We believe there is a unique window of opportunity to developer fairer, more accessible, and more global financial products on resilient public blockchains.

We are hiring for the following roles:

- Systems Engineer: https://jobs.ashbyhq.com/unto-labs/13df6bea-b253-4c80-ae05-5...

- Design Engineer: https://jobs.ashbyhq.com/unto-labs/81cbbb75-a75a-4d96-b5da-7...

- Product Engineer: https://jobs.ashbyhq.com/unto-labs/1ae2769b-1a67-41e2-a8d6-5...

Pex - part of Vobile Group | US | Full time [1]

We serve everyone who uses the Internet to view, share, or create content – from the largest platforms and rightsholders, to independent creators. Pex automated content recognition technology identifies uses that other tools can’t detect, including modified audio with speed, pitch, tempo, language, and other distortions.

We are hiring for the Senior Site Reliability Engineer (on-site, Gainesville, FL) [2]

We offer:

- Generous pay range based on skills and experience - Unlimited PTO + 10 paid holidays - Medical, dental, and vision insurance with FSA options, 401(k) plan - A supportive culture and excellent work-life balance To apply & learn more, reach out to us at Email is hidden!

—

[1] https://pex.com/ [2] https://pex.com/senior-site-reliability-engineer-07-2025/

Nomi.ai | Senior Machine Learning Engineer | Remote (Global) | Full-time | $150k–$250k + equity

At Nomi, we're building AI companions that form deeply meaningful, humanlike relationships and immersive roleplaying experiences. With over a million users growing at ~10% month-over-month, your work directly impacts millions of lives. Our users tell us we've helped them find self-worth, leave unhealthy relationships, try therapy, and even save their lives. See countless real user testimonials here: https://nomi.ai/spotlight/ and our recent news coverage here https://www.cnbc.com/2025/08/01/human-ai-relationships-love-...

As an ML Engineer or Senior ML Engineer, you'll lead innovation in large language model (LLM) post-training, retrieval augmented generation (RAG), and agentic capabilities, directly shaping how users connect with our AI.

We offer:

* Full autonomy to experiment and deploy cutting-edge ML techniques * A fully remote, async culture emphasizing results over meetings * International team with visa sponsorship available * For US employees: 401k (100% match up to 5%), fully covered health insurance, equity Great to haves:

* Extensive hands on experience with things such as multinode training, rlhf, knowledge distillation, test time compute, rag * Up to date with SOTA in LLM post training (would love to hear what research paper you think is or would be most impactful for our roadmap!) * Genuine passion for our product, finds the idea of engaging with our community on Discord/Reddit to be a pro (it is a very different experience than developing enterprise software!) * A high internal bar for excellence and relentless drive To apply, email Email is hidden with HN in the subject line.

Rad AI | Remote US, CAN (+ Office in SF) Empowering physicians with best-in-class AI radiology solutions to save time, reduce burnout, and improve patient care. Series C with tremendous momentum.

High-priority technical roles in ML+Speech, Senior Security Engineer, Application + Cloud, and lots of need for full-stack product engineering

Unique Business Operations & Strategic Initiatives Lead role for the Office of the CEO, reporting to the Chief of Staff.

Apply here >> https://www.radai.com/careers?utm_source=w29wy29rlj

DMI | Principal Full Stack Engineer | Munich, Germany | Full-time | ONSITE

DMI is a bootstrapped startup building the next-gen autonomy platform for defense & aerospace. Join us as Principal Full Stack Engineer to own and shape our product with the CTO.

You'll:

* Build high-performance frontends (Next.js, React, TypeScript)

* Integrate full-stack systems (FastAPI, Python, Rust)

* Optimize CI/CD and DevOps

* Mentor engineers and drive best practices

* Work directly with the CTO to shape product and technical strategy

You have:

* 5+ years building production software (3+ years frontend)

* Deep experience with our stack

* Strong DevOps/testing mindset

* Bonus: Real-time simulation, 3D/geospatial, or defense experience.

Why DMI?

* Product ownership, ESOP (employee stock option)

* A small, expert, high-impact team

* Great Munich office (simulator, BBQ, mountain views), mobility benefits, health and fitness benefits

Other software/ML roles open, just email me.

Interested?

Reach out directly to me (Pau): pgs(a)datamachineintelligence.eu

E2B | SF (US) or Prague (CZ), both on-site | [AI | Platform | Systems | Distributed Systems | Customer] Engineer/DevRel Engineer/Head of Engineering | https://e2b.dev/careers

E2B is an open-source infra devtool that gives AI agents cloud computers that we call sandboxes.

We're Series A startup with 7+ figures revenue. We've raised over $32M and have customers like Perplexity, Hugging Face, Manus, or Groq. We're growing double digits (sometimes triple digits) every month, have 5+ years of runway, and a full roadmap of exciting features to build.

I'd love to chat if you want to help us with some of the scaling challenges, DX, or new products!

Feel free to send me your projects to Email is hidden.

London, Newcastle and North UK | Remote (UK) with occasional travel | Full-time | https://www.literal-labs.ai

Hi are you based in the UK? We are looking for Junior, Mid to Senior Full Stack Engineers.

This is Leon, the CTO at Literal Labs. At Literal Labs, we build state of the art Machine Learning algorithms for the Edge and other targets that go brrr, and are looking for talented engineers to help us build web training tools to put these models in the hands of users.

Our mission is to create models that have a light touch on the environment, and that work for all.

This role is remote, though the right to work for a UK-registered company is required. Read here for more about how we work:

https://www.literal-labs.ai/careers/

And here more generally about some of the the company's technologies:

https://www.literal-labs.ai/tsetlin-machines/

But we are building out other techniques too!

Please email Email is hidden with the subject HN, and please cc me in too (Email is hidden). Thanks!