Uncountable | NY, SF, London & Munich (In-Person) | Full-Stack Engineering https://www.uncountable.com/hiring/hn

Uncountable accelerates R&D for industrial scientists across leading materials, chemicals, and life sciences organizations. With our SaaS solution, our customers get better products to the market in half the time. Uncountable was founded by MIT and Stanford engineers and has been profitable since 2016. Our team has grown from 50 to 100 over the last two years.

Full-Stack Engineers | $130k - $220k + Equity

---> Uncountable is looking for engineers who can spearhead the development of the Uncountable Web Platform. The position is heavily product-driven and comes with challenges across the stack.

LLM Applications Engineers | $130k - $220k + Equity

---> Uncountable is looking for LLM applications engineers who can push the Uncountable data model forward through LLM-native UI's and application extensions.

--> Summer internships and working student positions are also available.

Learn more: https://www.uncountable.com/hiring/hn

Uncountable is hiring in New York City, San Francisco, London, and Munich.

Contact our CTO directly at Email is hidden

Immunera | Principal Machine Learning Engineer | NYC area (hybrid) | Full-time | immunera.ai

Hey! I’m Maxim, cofounder/CEO of Immunera.

We're building blood tests that use gene sequencing and machine learning to help patients with autoimmune disease. Immunera spun out of years of research at Stanford, and our technology has been published in Science and covered by The New York Times.

We're hiring a Principal Machine Learning Engineer to shape the core models and infrastructure that power our blood tests. We are partnering with hospitals to generate training data from real patients for our language models and other biological sequence models.

This is a senior engineering role with significant autonomy at an early-stage, venture-backed startup. We're looking for strong experience building and operating ML systems in production (Python, PyTorch/TensorFlow, cloud platforms). Prior biology or healthcare experience is NOT required; we care much more about your ability to reason about data, models, and systems.

Full JD: https://www.immunera.ai/jobs

Contact: Email is hidden (subject: “HN ML job”)

Tech and Research roles | Remote (US) or on-site in Albuquerque

America First Policy Institute's Office for Fiscal and Regulatory Analysis is looking for coders, policy researchers (or the rare dual-skilled unicorns!) for several roles. Be part of the fastest growing public policy organization in America and do work with direct impact on your country.

https://www.americafirstpolicy.com/careers

Splash Tech| FE/Fullstack Mid-Senior/Senior | Remote( +-2 EU CET) | Full Time | https://splash.tech/

We’re a small UK-based free-to-play gaming company with a distributed EU team, growing fast after recent success and scaling our platform. We’re looking for a FE/Fullstack role, from mid-senior to senior engineer with at least 5+ years of experience.

Our engineers must be able to think product-first, and take a task from idea to production, work across the full cycle. You must write your own code, AI assistance is fine, but you must be able to produce all your work independently. We value clear thinking and communication, you should be comfortable sketching simple architecture or flow diagrams (boxes and lines, nothing formal) to explain your ideas.

You’ll also be asked to write SQL and some Java Controllers that access data. It’s ok if you don’t know Java, but our controllers are written in Java and you’ll need willingness to learn.

Our stack includes Java, Python, TypeScript, Angular, SQL.

To apply, please send an email to Email is hidden with the subject “FE/Fullstack Hackernews 2026”. Please send any git/bitbucket/source-forge project that represents your coding otherwise I’ll ask you to complete a small test project.

Silkline | Senior Software Engineer | Seattle | ONSITE (5 days/week) | $150k-$220k + equity | https://silkline.ai

Modern hardware supply chains run on spreadsheets, email, and PDFs. It's like fax woke up in 2025. We're fixing this with an AI-first procurement platform for aerospace, defense, and nuclear manufacturing.

Our customers: Machina Labs, Astranis, K2 Space, Castelion, Antares, and more. They use us to manage suppliers, track $M+ in orders, automate RFQs, and stay ITAR-compliant. Every day of production delay costs $50k+—our platform keeps them moving.

The role: Own features end-to-end, build ERP integrations that sync POs and manufacturing data, real-time order tracking dashboards, and a user experience that people LOVE. Work directly with customers whose supply chains depend on what you ship.

Stack: TypeScript, React, Next.js, Hasura (GraphQL), PostgreSQL, Trigger.dev, AWS GovCloud, Pulumi, Elbow grease.

You: 5+ years shipping production systems, strong full-stack or frontend generalist who moves fast, thrive on customer feedback and direct impact, bonus: ERP integrations, B2B SaaS, or regulated industries

Traction: 5x'd customer count last year, $5M funding to date, landing massive defense/space logos. Small team shipping incredibly fast—you'll work directly with our founders (Isaac and myself).

Apply: https://jobs.gem.com/silkline/am9icg9zddrlwseqtkka02ut_f9kgz... Questions? Email is hidden (mention HN)

Evervault | https://evervault.com | New York, London, Dublin, Remote | Full Time | Hybrid (3 days in office)

Evervault's mission is to make world-class data security effortless and pervasive. We use applied cryptography to secure the most sensitive data, in the most sensitive areas like payments, banking and healthcare. We build products to protect customer data with the latest advances in encryption and confidential computing, so our customers can minimize the headache of compliance and data security.

We are a small team (10 engineering, 25 overall) hiring across engineering, sales, marketing and finance for people who are passionate about building out our roadmap of products to protect companies from data breaches in a world where data has become gold.

Open roles:

- Senior Software Engineer (Payments) - Product Engineer - Design Engineer - Head of Finance & Ops Out stack is: Rust, Node.js (TypeScript), AWS

Apply here: https://evervault.com/jobs or ask me a question shane@

Fusionbox | Python + TypeScript Engineers | United States| Full-time | REMOTE (Legal to work in the US)

We're a software engineering consultancy that builds enterprise software the right way. We negotiate the right to open source all our client code, maintain a handful of popular libraries, and our engineers contribute to Django core. We sponsor PyCon, DjangoCon, and Django Girls because we're invested in the ecosystem we build on.

We're looking for software engineers who value software design, system architecture, and collaboration. You should be comfortable with about half of these areas and eager to learn the rest: web application security, relational database design (PostgreSQL, beyond "SELECT *..."), Django internals, React, and distributed systems. What you'll actually work on: complex state machines for financial workflows, multi-tenant architectures with row-level security, custom database functions when the ORM isn't enough, and React frontends that handle real-time data without being a mess of useEffect hooks.

We're a small team where you'll own features end-to-end (database design to React components) and have opportunities to shape technical decisions. You'll get paid to write source code with a team that practices empathy and values work-life balance. If you've ever wished your job involved more elegant state machines and fewer marketing landing pages, let's talk: Email is hidden.

MiLaboratories | Bilbao, Spain | ONSITE | VISA SPONSORSHIP | RELOCATION SUPPORT

We are MiLaboratories, the team behind Platforma.bio & MiXCR. We are building the "OS for Biology"—a platform that processes terabytes of genomic data to accelerate biological discovery and drug development.

We are a deep-tech research lab, not a typical SaaS. We work fully on-site in Bilbao because the complexity of our problems (high-performance computing + biological nuances) requires high-bandwidth, in-person collaboration.

We are hiring for three core roles:

1. Senior TypeScript Engineer (Desktop Platform / SDK): This is not a dashboard or a simple web GUI. You will build the architecture of our Desktop Platform—a high-performance local application that acts as the "OS" interface. You will deal with complex state management, massive data throughput, and bridge directly with our high-performance Rust data layer. We need someone who treats the browser engine as a runtime for heavy applications, not just for websites.

2. Senior Go Engineer: You will build distributed systems for high-load genomic data processing. This is not CRUD. We need someone who understands memory management, concurrency, and algorithmic efficiency at scale.

3. Bioinformatics Developer (Antibody Discovery): You will work on the scientific core, developing production blocks for NGS data analysis and antibody structure prediction. You should be fluent in both code and biology (Builder profile, not just analyst).

The Offer:

Comp: Top-tier EU salaries (~€90k - €120k).

Tax Advantage: Bizkaia has independent tax autonomy. You qualify for the "Special Impatriate Regime" (30% salary tax exemption + expense deductions).

The Reality: Your effective tax rate drops to ~15-20%, yielding a significantly higher net income than London or Berlin.

Stock: We grant ESOP and treat equity as a life-changing wealth vehicle, not a "nice to have."

Relocation: Comprehensive "Soft Landing" package (Visa, temporary housing, school search).

Location: Bilbao is a hidden gem—ocean, mountains, and high quality of life with a low cost of living.

Process: No HR screening. You will talk directly to the engineering team.

Email me (I am the CEO): Email is hidden. Please mention "HN" in the subject and include your GitHub.

Puma.tech | Remote-first with PST overlap | iOS/MacOS, Android, Ai/ML, Growth | https://puma.tech

Hi all, I’m Yuriy, founder of Puma.tech. Previously worked as software engineer & developer advocate at Cloudant (YC S08, Acq. by IBM), Meteor (YC S11), Parse (YC S11, Facebook/Meta), and explored AI/ML (computer vision for self-driving cars).

We have two products:

1. Puma Browser (iOS & Android) – browser with built in LLMs & Wallets. Private by design.

2. PumaAI app for Mac – ChatGPT/Atlas, but with ability to pick different model providers and fall-back to local-first ones for data privacy.

Open Roles: Eng (iOS/MacOS, Android, Ai/ML, Browser Extensions), Based Social Media Intern; Internships: Eng, Design, Growth

We’ve raised a few rounds from some of the best builders in crypto and ai:

Protocol Labs (YC S14), Chris Larsen (Ripple), Anatoly Yakovenko (Solana), Illia Polosukhin (NEAR Protocol), Sridhar Ramaswamy (Snowflake CEO, Neeva, Greylock), Jason Warner (poolside.ai, ex-GitHub CTO), Don Ho (Orange DAO, Quantstamp W18), Evil Rabbit (Vercel), John Phamous (SF Compute) and other amazing builders.

How to Apply: email Email is hidden with your GitHub, a note on what you're most proud of building and what you'd like to build next.

Thank you!

Hike Medical | Boston (ONSITE) | Senior+ Software Engineer

Hike Medical is reinventing musculoskeletal care, starting with feet. Our proprietary AI-vision platform turns a 30 second web based (yes, no sensors) foot scan into precision engineered, 3D-printed insoles that prevent pain before it starts. We're already protecting on-their-feet workforces at Fortune 50 leaders, major health systems, and middle America manufacturers. Fresh off a stealthy round with top tier VCs, we run a fast, no BS, execution first culture out of Boston’s Seaport as we sprint toward $100M ARR and standing with 10M Americans as they step into their shoes daily.

As a Senior Software Engineer, you’ll build and ship the core systems behind Hike’s AI healthcare platform. As the backbone of Hike's high-growth, mission-driven platform, you’ll design scalable services, implement production AI, and deliver user experiences that improve patient outcomes. From day one, you’ll have real autonomy and clear impact on transforming the US healthcare system.

What You'll Work On:

* Architect, build, and optimize high-performance, scalable systems that power AI-driven solutions.

* Design resilient, serverless architectures in a TypeScript and AWS environment.

* Develop developer-friendly APIs and SDKs that enable seamless integration across platforms.

* Build and refine high-speed data processing pipelines that drive clinical-grade AI insights.

Ideal Candidate Profile:

Technical Skills

* AWS & TypeScript Expert – Comfortable making infrastructure decisions, optimizing cloud deployments, and managing scalable architectures.

* Experience designing, building, and maintaining backend systems that power real-time, AI-driven applications.

* Strong experience in building and optimizing developer-facing SDKs and APIs. Skilled in real-time data processing pipelines and optimizing system performance at scale.

* A thoughtful approach to building secure, resilient, and fault-tolerant systems.

Helpful Characteristics

* Product-Minded Engineer – You think about how your work impacts real users.

* Strong Communicator – You clearly explain your ideas, challenge assumptions, and collaborate across engineering, AI, and product teams.

* Thrives in Collaboration – You push back, ask tough questions, and elevate the team.

* Driven to Ship – You want full control over your work, from architecture to deployment, and you’re eager to move fast.

* Mission-Focused – You’re not here to optimize ad clicks. You want to build technology that changes lives.

$150K – $225K • Offers Equity • $15k relocation bonus (if necessary)

Apply: https://jobs.ashbyhq.com/hike-medical/c5a39cb5-fdaa-457d-86d...