Tamarind Bio | Software Engineer | San Francisco ONSITE | https://www.tamarind.bio/

Tamarind hosts AI drug discovery models for biotech/pharma researchers. We’re building the infrastructure to power R&D in pharma companies and enable them to harness the latest advancements in computational biology, such as molecular ML models like AlphaFold.

We're hiring engineers who are excited to scale GPU inference, design intuitive applications for scientists, and build secure enterprise-grade software. We’re a series A company started 2 years ago, and have 10x’d revenue within the past year. We’re used by 7 of the top 20 pharma, dozens of biotechs, and tens of thousands of scientists. We’re hiring for a variety of engineering roles, including generalist software engineers and infrastructure engineers. We value ownership, moving quickly, and a focus on customer needs.

Stack: AWS, Python, React, Javascript, Kubernetes

Apply here: https://www.ycombinator.com/companies/tamarind-bio/jobs or email me at Email is hidden.

Octane | Staff Platform Engineer | REMOTE (US only)

Octane is the #1 Powersports lender in the US and has expanded into other verticals, such as RVs, marine vehicles, and autos.

Our Platform Engineering team plays a critical role in building and maintaining the highly reliable, scalable, and secure infrastructure that powers our business. We are seeking a seasoned Staff Platform Engineer to serve as the technical lead for the team. This leadership position will be responsible for shaping the strategy, architecture, and delivery of our core platform services while mentoring engineers and guiding best practices across the organization. The ideal candidate has deep expertise in AWS and cloud infrastructure and thrives on solving complex challenges at scale.

Full job description: https://octane.co/o/who-we-are/careers/jobs-open/?gh_jid=741...

Octane on LinkedIn: https://www.linkedin.com/company/octane-lending/posts/?feedv...

Note: I direct our data and platform teams, so you would report to me. Happy to answer questions.

Noise | Senior Software Engineers (Frontend, Mobile) | NYC | ONSITE | Full-time | $160k-$210k + equity

Noise is building a way to measure and trade attention — something the internet produces endlessly but no one has been able to objectively track. We create a transparent, real-time market for attention itself, revealing what the world actually cares about as it changes.

Team of 10 in SoHo. We look for people with great taste who ship code, design, or convey user needs into delightful products.

Hiring:

Senior Frontend Engineer — Own and ship features across the stack with a frontend focus. Work closely with design to build fast, reusable components. React, TypeScript, Tailwind.

Senior Mobile Engineer — Architect and build our React Native app from zero to launch. Own performance, motion, and polish. Every frame and gesture should feel native.

For both: Not a vibecoder. Uses Cursor or similar to empower, not replace. Strong attention to detail, self-QA, taste for motion and interaction.

Apply: https://jobs.ashbyhq.com/noise-labs

[PALTOWN Development Foundation] | Full Stack Developer - HIPAA Project | Remote | Contract $35-50K

Cancer patient support and education nonprofit needs experienced full-stack dev for meaningful 10-12 week contract.

PROJECT: Build secure, mobile-friendly front-end for Airtable database with SSO integration (Hivebrite), (potentially) HIPAA-compliant AWS hosting with BAA, and PDF export functionality.

STACK: Your recommendation (we prefer React/Vue + Node.js/Python, AWS with HIPAA compliance)

REQUIREMENTS: * HIPAA-compliant app development experience * SSO/IdP implementation * AWS with Business Associate Agreement setup * Airtable API integration * Clear communication with non-technical stakeholders

SCALE: Small, includes de-identified patient information, straightforward data interface

WHY IT MATTERS: Help cancer patients find treatment options that could extend their lives.

Details here: https://docs.google.com/document/d/1z8fwtmdhjndbdh11sz8_707b...

Uncountable | NY, SF, London & Munich (In-Person) | Full-Stack Engineering https://www.uncountable.com/hiring/hn

Uncountable accelerates R&D for industrial scientists across leading materials, chemicals, and life sciences organizations. With our SaaS solution, our customers get better products to the market in half the time. Uncountable was founded by MIT and Stanford engineers and has been profitable since 2016. Our team has grown from 50 to 100 over the last two years.

Full-Stack Engineers | $120k - $220k + Equity

---> Uncountable is looking for engineers who can spearhead the development of the Uncountable Web Platform. The position is heavily product-driven and comes with challenges across the stack.

--> Summer internships and working student positions are also available.

Learn more: https://www.uncountable.com/hiring/hn

Uncountable is hiring in New York City, San Francisco, London, and Munich.

Contact our CTO directly at Email is hidden

Prodia | Fastest Inference API | London / REMOTE (US or Europe) | Software Engineer

Engineers at Prodia build the systems that make image + video generation fast, reliable, and easy for developers to use.

This is a highly practical role: shipping models, features, and improvements that show up directly in latency, quality, and uptime.

Sample projects include… * Optimising, testing, and integrating frontier image/video models (research -> production) * Building the best APIs for developers: clean ergonomics, great docs, predictable behaviour * Designing evals + observability: catching regressions, ranking outputs, and understanding quality changes * Improving our distributed job scheduling (throughput, latency, fairness, cost) * Reading the latest papers to gather methods for future improvements * Using the newest AI/agentic tooling to speed up debugging, experimentation, and iteration

You might be a fit if… * You’re an excellent programmer and love shipping quickly * You're a first principles thinker who is unfazed by hard problems * You're looking to learn more about machine learning at a rapid pace * No specific degree or background required — show us what you’ve built and how you think

Please email me: monty at prodia dot com. If you're in London, I'd love to buy you coffee and learn more about you.

Prompt Health| Senior Full Stack Engineer, Senior DevOps Engineer, Support Engineer | REMOTE (US)

Prompt Health is a fast-growing Healthcare SaaS company with over $100M in ARR, growing 100%+ YoY. We build software used by large healthcare organizations to operate more efficiently and deliver better patient care.

We ship hundreds of features and products each year with a small, highly collaborative engineering and product team. Engineers have real ownership, work closely with product and customers, and influence technical direction.

Roles

- Senior Full Stack Software Engineer: $200k-$225k Build and scale core B2B SaaS product features. Work across frontend, backend, APIs, and data. Collaborate closely with product and design. Tech: PHP (Laravel), Vue.js, MySQL, AWS. High-traffic B2B SaaS

- Senior DevOps Engineer: $200k-$225k Own cloud infrastructure, CI/CD, reliability, and observability. Improve deployment speed, system stability, and security. Tech: AWS, Kubernetes, Terraform, CI/CD, Datadog

- Support Engineer: $90k-$125k Debug complex production issues. Work closely with customers and engineering to identify root causes and improve the product. Tech:PHP/Python, SQL, REST APIs, AWS

- Senior AI Engineer (Natural Language Systems): $160k–$220k Build real-time AI systems for speech and language understanding. Own NLP and LLM pipelines with a focus on accuracy, latency, and cost. Partner with Product and Engineering to ship production AI features. Tech: Python, NLP, LLMs, Speech-to-Text, Docker, AWS

- Senior AI Engineer (Rapid Prototyping & Analytics): $160k–$220k Prototype and ship end-to-end AI systems across ML and LLM workflows. Own evaluation, monitoring, and guardrails for AI pipelines. Translate business workflows into practical AI solutions. Tech: Python, LLMs, ML, Evaluation, Docker, AWS

Competitive compensation, equity, and benefits. We are actively hiring and will respond to applicants!

Apply here: https://www.prompthealth.com/careers#list

Aha! (https://www.aha.io) | Rails / React / Devops | REMOTE

Aha! is the #1 tool for product managers to plan strategy and roadmaps. We serve more than 700,000 users worldwide. We are looking for:

* Experienced Rails security engineer to work on the Aha! product. Our application is built in Ruby on Rails, with React on the frontend for rich client-side experiences.

Aha! is profitable, you can work from anywhere in North or South America, and we offer excellent benefits. We use our own product to manage our work (which is especially rewarding) and we deploy continuously.

Our entire team has always been 100% remote - in North American timezones so we can collaborate during the work day.

Amperos Health (https://www.amperoshealth.com/) | NYC | Full-time | Engineers & PMs

Amperos Health is building AI agents to automate healthcare revenue cycle workflows so clinics get paid faster and staff can focus on patients. We’re a fast-growing startup with real customers and production AI systems in the wild.

We’re hiring across: - Software Engineers (Full-stack, Infra, Integrations)

- AI / Research Engineers

- Product Managers (Agents, Integrations)

- Design Engineer & AI Deployment roles

We’re looking for people who enjoy high ownership, shipping quickly, and applying AI to real-world problems.

Our full postings are available here: https://jobs.ashbyhq.com/amperos

Email me at Email is hidden if you're interested!

Stardrift (https://stardrift.ai) | Founding Engineer | Onsite - SF | Full time

Hi HN - I'm the founder of Stardrift, and we're looking for a founding engineer to join our team of 3.

We are building a world-class travel agent experience. In the future, you won’t book travel by opening ten tabs in Google Flights; you’ll book through a personalized AI assistant that understands everything about you and automatically arranges your trip for you.

You'll tackle everything from optimizing LLM performance and building evals to integrating with APIs for rail and flight networks around the world. We care about moving fast and writing high-quality code; your job will be to take customer feedback and improve our product, working with me & the rest of the founding team.

Here's a tech blog we wrote about some of the systems engineering we do: https://stardrift.ai/blog/streaming-resumptions.

You can find more info at https://www.ycombinator.com/companies/stardrift/jobs/nc7cjhb.... Email Email is hidden to apply.