Culture Biosciences | https://www.culturebiosciences.com | Senior Software Developer (Bioprocess Automation) | Hybrid South San Francisco, CA | $180k–$210k + equity

We build cloud-connected bioreactor systems that let biotech companies design, run, and analyze upstream bioprocess experiments faster. You’ll own software that automates and controls bioreactors, instruments, and analyzers, working across the stack from embedded/edge control loops (pH, DO, temperature, agitation, feeding strategies) up to cloud-native data and workflow apps.

We’re looking for someone with ~8+ years combined experience in bioprocess/automation + software engineering, strong Python and Docker/IaC skills, and experience interfacing with physical systems. You’ll collaborate closely with scientists, process engineers, and hardware teams, and mentor other engineers on a small, multidisciplinary team.

More details & apply: https://www.culturebiosciences.com/careers?gh_jid=7358174003

Feel free to reach out to me if you have questions jonathan.meed @ company domain

SentiLink | https://www.sentilink.com/ | Engineering & Data Science | REMOTE, HYBRID, and ONSITE (USA & INDIA) | Full Time

At SentiLink, we stop identity fraud at scale. Our products protect banks, fintechs, marketplaces, and leading financial institutions from synthetic identity fraud, identity theft, and emerging threats — analyzing millions of applications while keeping real users moving fast.

We’ve seen tremendous traction and are growing extremely quickly. Our real-time APIs have helped verify hundreds of millions of identities, starting with financial services and rapidly expanding into new markets. SentiLink is backed by world-class investors including Craft Ventures, Andreessen Horowitz, NYCA, and Max Levchin.

SentiLink supports a variety of ways to work, ranging from fully remote to in-office. We operate as a digital-first company with strong collaboration across the U.S. and India. We maintain physical offices in Austin, San Francisco, New York City, Seattle, Los Angeles, and Chicago in the U.S., and in Gurugram (Delhi) and Bengaluru in India. If you’re located near one of these offices, we would love for you to spend time in the office regularly. Some roles are hybrid or in-office by design. For example, our engineering team in India works primarily from our Gurugram office.

We’re a small, high-impact team solving one of the most interesting and adversarial problems in fintech: how do you build systems that reliably determine whether a real human is on the other side of a financial transaction?

We’re hiring across Engineering (Full-stack and Infra) and Data Science / ML roles. Hiring at Manager/Director level as well as mid-level/Senior levels.

We’re language-agnostic and hire for fundamentals. Across the team you’ll see: • Python, Go, Rust, Scala • PostgreSQL, Snowflake • Kafka, Redis • Terraform, Kubernetes • ML: XGBoost, PyTorch, Feature stores, real-time scoring pipelines

If you love solving complex distributed systems challenges, building customer-facing ML products, or working on detection systems that must be both high-precision and low-latency, you’ll fit right in.

Roles are here: https://jobs.ashbyhq.com/sentilink?utm_source=hacker_news

If you have questions, feel free to reach out directly at liz.woodfield at sentilink dot com.

ParadeDB | https://paradedb.com | SF Onsite + Remote | Full-Time | Rust Database Engineers

ParadeDB is an alternative to Elasticsearch built on Postgres. We're building a Postgres extension in Rust that offers a new index type optimized for full-text search and aggregate/analytics workloads. We solve three problems with Elasticsearch today:

- Lack of read-after-writes guarantees

- Lack of JOINs

- Infrastructure complexity & cost due to syncing Postgres and Elastic.

We're open-source, and our repository is available at https://github.com/paradedb/paradedb. We're a Series A team of 8 distributed across the US and Canada. Most folks on our team have 10+ years of experience in database internals at companies like Twitter, MongoDB, Oracle, Instacart, etc.

You can find our roles and the profiles of our team members here: https://paradedb.notion.site

If you know Rust and/or have experience working on DB internals and want to work on cool systems problems, shoot us a note. We hire with conviction, have lots of room to grow, and exciting technical problems to solve. My email is Email is hidden.

PUNTT.ai | Founding Enterprise Account Executive | Full-time Founding Role | Hybrid in San Francisco

Our mission is to kill the review — and free people to do meaningful work.

Partner directly with the Founders and CEO to build and scale our enterprise motion from the ground up. If you’re excited about selling in an AI-first environment, shaping GTM in real time, and owning revenue in a fast-moving zero-to-one environment — this is your lane.

Ideal profile: – 7-10 years experience - 2+ years CPG (consumer packaged goods) experience or connections – Experience working with Marketing, Creative, or Operations orgs is a strong plus – Someone who thrives in startups, ambiguity, loves refining the narrative, and wants a front-row seat to building an AI category

More info & apply: https://wellfound.com/l/2bkuin

ArcPrime | http://arcprime.com/ | Remote | Full Time | Full Stack Developer

ArcPrime just closed a seed round to build the best-in-class AI tools for Intellectual Property attorneys.

We have a world-class team of 6 engineers (CEO is an attorney + engineer) uniquely positioned to win the entire market. We thrive on execution speed, know our customer and domain to the most intimate detail, and are relentless.

We empower our people to do their best work and grow to their fullest potential. We value impact above all else. We offer highly competitive salaries and top-of-market equity. We plan on hiring fewer than 10 engineers for the lifetime of the company. If this sounds exciting to you, please apply!

Stack: React, Typescript, TailwindCSS, and Google Cloud

Email me with your resume to apply: jon @ domain

Full job description: https://docs.google.com/document/d/1r3jzyv8yvmjgspvddyhwktzk...

Hightouch | Multiple Roles | Remote | Full-time | $180,000 - $320,000 USD + equity

Hightouch is the modern AI platform for marketing and growth teams. Our AI agents reimagine marketing workflows, allowing marketers to create content, plan campaigns, and execute strategies with transformational velocity and performance. Hightouch is a rare company built on the intersection of two fundamental technological shifts: advances in LLMs and agentic AI, and the creation and rapid adoption of cloud data warehouses like Snowflake and Databricks. Building on these tailwinds, we’ve become a leader in AI marketing and partner with industry leaders like Domino’s, Chime, Spotify, Ramp, Whoop, Grammarly, and over 1000 others. Our team focuses on making a meaningful impact for our customers. We approach challenges with first-principles thinking, move quickly and efficiently, and treat each other with compassion and kindness. We look for team members who are strong communicators, have a growth mindset, and are motivated and persistent in achieving our goals.

Open Roles: Backend Engineer, AI Content Agents Developer Productivity Engineer Full Stack Product Engineer ML Engineer, AI Decisioning Software Engineer, AI Agents Software Engineer, Control Plan Software Engineer, Customer Studio Backend Software Engineer, Distributed Systems Software Engineer, Journeys https://hightouch.com/careers#open-positions

We are committed to reviewing all applications

Opendoor (https://www.opendoor.com) | In Person | San Francisco, CA | Full-time We're hiring engineers across the stack at Opendoor. We're building technology to simplify residential real estate - making it easier to buy and sell homes. Our engineering challenges span everything from marketplace dynamics and pricing models to complex operational workflows and integrations with industry systems. If you're interested in applying technology to modernize a massive, traditional industry, we'd love to hear from you. yan at [our domain].com :D

Silk Hedge Fund | https://silk.fund | Co-founder | In-person NYC

Silk is a full-stack AI hedge fund utilizing large language models to orchestrate the complete spectrum of investment workflows. We are building the infrastructure for truly autonomous wealth generation, replacing legacy workflows with systems that allow LLMs to compete with and outperform human investors. We are looking to bring on founding members who have technical backgrounds in quantitative finance, ML/AI, and risk management.

Hi, I'm Alek Turkmen, solo founder working on Silk full time now for the past 3 months. Please reach out if interested. Also looking for advisors / mentors with finance background.

Email -> Email is hidden | https://www.linkedin.com/in/alekturkmen/ | https://alekturk.men

Sumble is the newco from the founders of Kaggle. We are hiring a designers, full stack engineers and ai/ml engineers.

Can view our roles and apply here: https://apply.workable.com/sumble-inc/ We are building a knowledge graph from web data with a first focus on data for go-to-market teams.

We use web data to identify things like org structure, tech stack, and key projects (e.g., GenAI initiatives, cloud migrations). Our product already has strong product-market fit, early revenue, and happy customers — and now we’re ready to accelerate.

Our long-term vision is to become the world's best data vendor. Try the product at sumble.com.

We are a team of 19 with experience at companies such as Google, Meta, Stack Overflow, Rippling, Snowflake, Confluent and Kaggle.We just announced a $38.5MM financing: https://techcrunch.com/2025/10/22/sumble-emerges-from-stealt...

tulanā | full time | Berlin / remote with some presence in Berlin | Senior Software Engineer | https://tulana.notion.site/senior-software-engineer-2a3f6680... We are a bootstrapped, profitable startup leveraging stochastic optimization / OR, simulation, and machine learning to optimize decisions at scale in complex supply chains and transport networks. What we love: Scala and Nix, principled and reliable solutions and suckless systems.

Feel free to get in touch directly with the CTO: https://www.linkedin.com/in/maxbarkhausen/ | Email is hidden