BillionToOne (YC S17) | Menlo Park, CA; on-site or hybrid (US only) | Full-time BillionToOne is ranked at the top 5% of Y Combinator companies with close to $400M in funding. In June 2024, we closed a $130M Series D resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. We have developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000x. Our first product, Unity, is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for: common and severe recessive gene disorders; chromosomal abnormalities; fetal sex; and fetal antigens from a single tube of blood from the pregnant mother. This greatly improves the quality of care and is on its path to becoming the next standard-of-care.

Our software stack includes Python/Django, React/Typescript, Terraform, AWS, and many other standard tools. We're a small, but nimble software team that prioritizes rapid iteration and continuous feedback to evolve our product. As a biotech company, we inherently need to always work cross functionally. If you enjoy this style of work, please reach out!

We're hiring software engineers, bioinformatics engineers, and many other roles. You can email me directly at Email is hidden with your resume or apply through the links below.

- Senior Software Engineer, Frontend: https://job-boards.greenhouse.io/billiontoone/jobs/436548500...

- Bioinformatics Associate, Prenatal: https://job-boards.greenhouse.io/billiontoone/jobs/434501600...

You can view all open roles on our careers page: https://billiontoone.com/careers/open-positions/.

Franklin Templeton | Quant Implementation Lead | Boston, MA | In-Person | $145k - $190k + Bonus

We're building an end-to-end portfolio construction system to support FTIS, a $100bn multi-asset investment manager within FT. This is a front office role that will help guide our quantitative staff as we build out this new system. This project is a strategic objective for FTIS, highly visible, and frankly one of the most fun jobs in the industry.

We're looking for mid to senior level researchers or developers with strong buy-side backgrounds who can help translate our investment process into a robust, scalable, and approachable design.

Reach out with any questions - Email is hidden

Apply here: https://franklintempleton.wd5.myworkdayjobs.com/primary-exte...

Comulate | Senior Engineer (3+ YoE) | ONSITE in San Francisco, CA

We're building automation software for the $7T insurance industry, accelerated by AI. Seed stage in terms of headcount (~ 20 people) but Series B in terms of business traction (+ cash-flow positive). We've intentionally stayed under the radar.

- Product has caused customers to literally cry tears of joy

- Experienced eng team from Airbnb / Brex / LiveRamp

- Stack: TS, Postgres, React, GraphQL, and Next.js

Apply here: https://comulate.com/careers

Pocketflows | Founding Engineer | San Francisco, CA | In-person | $170k-225k + equity | pocketflows.com

At Pocketflows, we’re on a mission to help Main Street SMBs grow. We build marketing and communication APIs that embed inside the vertical SaaS platforms that businesses like salons, fitness studios, and restaurants already use to run their operations.

As a founding engineer, you'll be launching new marketing products in addition to our existing email, SMS, and review platform.

Our values blend ambition with kindness and empathy.

Stack: Ruby on Rails, React + TypeScript, TailwindCSS, Postgres, Redis

Interested? Email us at Email is hidden with your resume/LinkedIn/GitHub, a note on why you'd like to join, and an answer to this riddle:

"I'm thinking of a secret number hidden on pocketflows.com. I won't console you if you can't figure it out"

Loman AI | Founding Engineer | Austin, TX | Hybrid | Full-Time | $175k - 225k + equity | https://loman.ai

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We are building the best-in-class phone AI for restaurants, enabling autonomous agents to handle orders, reservations, and customer inquiries. As a founding engineer, you’ll shape our core product while working directly with cutting-edge LLMs, developing third-party integrations, and designing scalable APIs.

Unfortunately, we cannot offer visa sponsorship.

Stack: nodejs, typescript, postgres, fastify, docker, redis, react

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Apply at Email is hidden

Digital Onboarding | Senior Full-stack Engineer | REMOTE (US based) | Full time

Digital Onboarding is a marketing automation platform that helps banks and credit unions modernize their onboarding process and develop mutually beneficial, profitable relationships with their customers and members.

Stack: Elixir + Phoenix, React, Postgres

https://digitalonboarding.applytojob.com/apply/ezmydbyg7a/sr...

Monad Foundation | https://www.monad.foundation/ | Remote | $225M Series A Funded

We are actively hiring Engineers to build software and facilitate the adoption of the Monad blockchain. Key roles include: 1. Senior Protocol Engineer 2. Full Stack Engineers 3. Devrel Relations Engineers

The full list of roles is here: https://jobs.ashbyhq.com/monad.foundation?utm_source=jglvj5y...

Samsung Research America, Mountain View is hiring Multiple Speech Research Role [5+ yrs experience]. Both Speech to Text ASR, and Text to Speech TTS, Speech to Speech roles. You will get to work on cutting edge AI Speech Research.

TTS - https://job-boards.greenhouse.io/samsungresearchamerica/jobs...

We offer - Competitive base salary, bonus, 401k email me resume at Email is hidden

Full Time and Part Time roles Distark is hiring, an edutainment brand building learning videos for Education. Our small, passionate team creates animated shows and learning tools that help kids (ages 3-9) fall in love with curiosity and real-world learning. We use custom automation to speed up everything from story writing to animation. See what we’re making: https://www.youtube.com/watch?v=c46vam_vzgu

Open Roles (REMOTE, non US):

Animators (2D/3D or hybrid—experience with AI tools a plus)

Junior Software Developers (Python, Node, JS, or open to learning new tech)

Interns (all backgrounds, generalists, tech, or creative)

We are also looking for writers (different kind of hacking)

Important: You must be a parent (of any age child) We want people who care deeply about kids and learning. Lived experience as a parent is essential—our mission is to build things real families want.

Why join us?

Fully remote, async-friendly Ship real things that impact how kids learn Fast, creative, zero-corporate-BS environment

Direct access to founders; real ownership

Opportunity to shape our tools and shows from the ground up

To apply: Email Email is hidden with your background, a few sentences about your kids, and why this mission excites you. Please include links to any relevant work.

We are the hiring company and will reply to all genuine applicants. No recruiters, no agencies, please.

Comity Inc. | Platform Software Engineer | Hybrid (Brooklyn, NYC)| Full-time

Comity is on a mission to improve the reliability, transparency, and efficiency of our energy systems, fostering a future with sustainable and abundant energy. Our team is leveraging statistical learning and convex optimization methods to build the financial rails of our future energy systems that will accelerate the deployment of clean energy resources.

You can read the full JDs and apply here: https://jobs.ashbyhq.com/comity?utm_source=hacker_news